| Main Title |
Micronucleus Test of Cumene with Cover Letter. |
| CORP Author |
Gulf Oil Exploration and Production Co., Oklahoma City, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
878216015 |
| Stock Number |
OTS0206782 |
| Additional Subjects |
Toxicology ;
Health effects ;
Cumene (98-82-8) ;
Genotoxicity ;
Chromosomal Effects ;
Mammals ;
Mice ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 98-82-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206782 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
25p |
| Abstract |
The ability of cumene to induce micronuclei in bone marrow polychromatic erythrocytes of groups of 10 male and 10 female Crl:CDR-1(ICR)BR Swiss mice was evaluated at dose levels of 0.25, 0.50, 1.00 (2 doses), and 1.00 (1 dose, 15 animals) g/kg administered in paraffin oil by gavage once daily for two days using bone smears prepared, half on day 3 and half on day 4, following onset of dosing. Dose levels were based on prelim- inary toxicity studies. No significant (p<=0.05) increase occurred in any cumene dose group relative to controls, although the positive control, admin- istered 75 mg/kg cyclophosphamide intraperitoneally, didshow a difference (p<=0.05). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801070 |
| Origin |
NTIS |
| Type |
CAT |
