| Main Title |
Letter to Usepa Regarding Enclosed Mouse Sensory Irritation - Method Verification Study on 2-propenal with Attachments (Sanitized). |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
86-920000386S |
| Stock Number |
OTS0533724 |
| Additional Subjects |
Toxicology ;
Health effects ;
Confidential ;
2-propenal (107-02-8) ;
Acute Toxicity ;
Mammals ;
Mice ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 107-02-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0533724 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
20p |
| Abstract |
Acrolein (CAS No. 107-02-8) with several other chemicals was evaluated for sensory (upper airway) irritation in a modified Alarie Mouse Sensory Irritation Test. Four each male Swiss Albino CD-1 mice were administered dynamic head only exposures to vapor concentrations of 0.0 to 8.7 ppm in air over 10 minutes to characterize type response as either immediate and persisting, immediate with accommodation (ameliorated with time), or immediate and progressive during exposures. Concentrations below 2 ppm produced a linear response (breaths/minute/animal) curve, while maximal responses (decreased respiration rate) occurred after 10 minutes' exposure, thus indicating a progressive response to exposure without physiological accommodation or compensation; an RD50 (linear regression determination of that concentration causing 50% reduction of respiratory rate) was 1.27 ppm (R=0.89; 95% CL 1.07-1.52 ppm). Response data were not provided. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1991 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803180 |
| Origin |
NTIS |
| Type |
CAT |
