| Main Title |
Letter from Dow Corning Corp. to USEPA regarding Toxicity of Dimethyl Silicones and Siloxanes (Dow Corning 360 Fluid) with Attachments, dated 10/06/1995. |
| CORP Author |
Food and Drug Research Labs., Inc., Waverly, NY.; Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1995 |
| Report Number |
OTS-86960000053 |
| Stock Number |
OTS0558193 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Dimethyl silicones ;
Siloxanes ;
Laboratory animals ;
Subchronic toxicity ;
Mammals ;
Rats ;
Parenteral ;
Subcutaneous ;
Intramuscular ;
Intraperitoneal ;
Chronic toxicity ;
Combined chronic toxicity/carcinogenicity ;
Acute toxicity ;
Rabbits ;
Mice ;
Monkeys ;
CAS No 63148-62-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558193 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
42p |
| Abstract |
These studies first initiated in 1962 with the specific objective of providing additional evidence of systemic safety to add to the then sparse data provided by Rowe, Spencer and Bass (532) . The body of animal safety information developed by Ashley and co-workers adds immeasurably to the history of preclinical safety associated with DOW CORNING 360 Medical Grade Fluid administration. The absence of significant untoward symptomatology, or of any significant treatment related tissue pathology, are supportive to the findings of other investigators discussed in this submission. Seen in its critical dimensions, the findings in rodents, and in the subhaman primates, correlate in all respects with the observations derived from the extensive human experience available. The data have been prepared in a form to permit examination of elements with respect. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
3 Nov 1995 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500910 |
| Origin |
NTIS |
| Type |
CAT |
