| Main Title |
Initiation, Promotion, and Complete Carcinogenesis by N-Methyl-N'-Nitro-N-Nitrosoguanidine or Ethylnitrosourea in the SENCAR Mouse Skin Tumorigenesis Model. |
| Author |
O'Connell, J. F. ;
Nesnow, S. ;
Slaga, T. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC.;Texas Univ. System Cancer Center, Smithville. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/318; |
| Stock Number |
PB88-196043 |
| Additional Subjects |
Nitro compounds ;
Carcinogens ;
Skin cancer ;
Mice ;
Neoplasms ;
Pharmacology ;
Toxicity ;
Reprints ;
Ethylnitrosourea ;
Methylnitronitrosoguanidine ;
Skin neoplasms ;
Papilloma ;
Cocarcinogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-196043 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Five doses of either N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 micromol. As complete carcinogens, MNNG from doses of 0.5-5.0 micromol and ENU from doses of 10 micromol-40 micromol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.) |
| Supplementary Notes |
Pub. in Cancer Letters, v37 p301-310 1987. Sponsored by Texas Univ. System Cancer Center, Smithville. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Initiation, Promotion, and Complete Carcinogenesis by N-Methyl-N'-Nitro-N-Nitrosoguanidine or Ethylnitrosourea in the SENCAR Mouse Skin Tumorigenesis Model. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57E; 57Q; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
817624469 |
| Origin |
NTIS |
| Type |
CAT |
