| Main Title |
Initial Submission: Teratogenicity Study with Xylene in Mice with Cover Letter dated 07/22/92. |
| CORP Author |
Research Triangle Inst., Research Triangle Park, NC.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920005518 |
| Stock Number |
OTS0544772 |
| Additional Subjects |
Toxicology ;
Health effects ;
Xylene ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Mice ;
Toxic substances ;
Laboratory animals ;
CAS No 1330-20-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0544772 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
62p |
| Abstract |
Xylene (CAS No. 1330-207) was evaluated for developmental effects in mice administered the test substance by gavage at dose levels of 0, 0.6, 1.2, 2.4, 3.0, 3.6 or 4.2 mL/kg/day. There were 15/15 mortalities at 4.2 mL/kg/day and 12/38 at 3.6 mL/kg/day. Maternal body weight gain was reduced in survivors at 3.6 mL/kg/day (p<0.05). The average maternal liver weight was increased at 2.4 and 3.0 mL/kg/day and the average fetal weight was reduced at 2.4 and 3.0 mL/kg/day (p<0.05). The average percent of malformed fetuses was increased at 2.4, 3.0, and 3.6 mL/kg/day (p<0.01). Cleft palate was observed in the 1.2, 2.4, 3.0, and 3.6 mL/kg/day groups. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Rohm and Haas Co., Philadelphia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803630 |
| Origin |
NTIS |
| Type |
CAT |
