| Main Title |
Initial Submission: Subacute Inhalation Toxicity of Butyraldehyde in Rats, Mice, Guinea Pigs, Rabbits, and Dogs with Cover Letter dated 09/01/1992. |
| CORP Author |
Carnegie-Mellon Inst. of Research, Pittsburgh, PA.; Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0892-10075 |
| Stock Number |
OTS0570659 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Butyraldehyde ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
Mice ;
Guinea pigs ;
Rabbits ;
Dogs ;
CAS No 123-72-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0570659 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19p |
| Abstract |
Rats, mice, guinea pigs, rabbits and dogs were exposed to butyraldehyde vapor 6 hours/day, 5 days/week for 9 days over a two-week period. The measured concentrations for the 3 test levels were 6400, 3100 and 2000 ppm. Definite signs of eye and respiratory irritation, and statistically significantly lower body weight findings were observed in most species inhaling 6400 and 3100 ppm of butyraldehyde. Other signs observed in most animals at 6400 ppm included coordination loss, anesthesia and death. At 3100 ppm these effects were observed only in the beagle dog. Only some eye and respiratory irritation and statis- tically significantly lower body weight effects were observed among animals inhaling 2000 ppm of butyraldehyde. Scattered organ weight effects were found in rats for both test groups (3100 and 2000 ppm) surviving the 9-day inhalation treatment. (Further interpretation of these organ weight findings will probably be forthcoming in the following 13 week study.) No pathologically significant treatment related gross lesions were found among animals inhaling 3100 or 2000 ppm of butyraldehyde. One male Sprague-Dawley rat that had been exposed to 6400 ppm had bilateral bemorrhage of the ethmoturbinates. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
31 Aug 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010502810 |
| Origin |
NTIS |
| Type |
CAT |
