| Main Title |
Initial Submission: Pathology Results from a Two-Year Chronic Dermal Study of Diethanolamine in B6C3F1 Mice with Cover Letter dated 05/03/1996. |
| CORP Author |
Battelle Columbus Div., OH.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1996 |
| Report Number |
8EHQ-0596-13642 |
| Stock Number |
OTS0558516 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Diethanolamine ;
Chronic toxicity ;
Carcinogenicity ;
Mammals ;
Mice ;
Dermal ;
CAS No 111-42-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558516 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
B.C,F, mice were exposed dermally for two years at diethanolamine doses of either 0, 40, 80, or 160 mg/kg. According to the interim report, incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatablastoma were greater in treated male and female mice compared to control animals. Also according to the interim report, incidences of renal tubule adenoma were greater in treated male groups than in controls. The interim report further states that the Pathology Working Group Chairman confirmed the absence of liver lesions consistent with Helicobacter infection; however, the report did not describe the specific methods used to rule out the presence of Helicobacter infection. In fact, certain methods may not detect the presence of this bacteria. Helicobacter infection is a major tumor risk factor, and Helicobacter has been detected recently in animal colonies being supplied to the National Toxicology Program. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
6 May 1996 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500270 |
| Origin |
NTIS |
| Type |
CAT |
