| Main Title |
Initial Submission: Isophorone: Significance of the Toxicology and Carcinogenicity in Fischer 344 Rats and B6C3F1 Mice with Cover Letter dated 09/24/1992. |
| CORP Author |
Papanicolaou Cancer Research Inst., Miami, FL.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-11057 |
| Stock Number |
OTS0571092 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Isophorone ;
Chronic toxicity ;
Carcinogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Mice ;
CAS No 78-59-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571092 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
Isophorone when administered in corn oil and by stomach tube at dosage levels of 250 or 500 mg/kg was associated with an increased incidence of renal and preputial tumors in male rats, an increased incidence of liver tumors in male mice, but did not exhibit carcinogenic potential in either female rats or mice. Thus, under the conditions of this bioassay, isophorone appeared to exhibit weak carcinogenic activity. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
24 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800820 |
| Origin |
NTIS |
| Type |
CAT |
