Main Title |
In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer. |
Author |
Hozier, J. ;
Applegate, M. ;
Moore, M. M. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Florida State Univ., Tallahassee. Dept. of Biological Science. ;Florida Inst. of Tech., Melbourne. Medical Genetics Lab. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/448; |
Stock Number |
PB93-141471 |
Additional Subjects |
Carcinogenesis ;
Toxicology ;
Mutagenicity tests ;
DNA mutational analysis ;
DNA probes ;
Cultured cells ;
Mice ;
Genetic markers ;
Genetic models ;
In vitro analysis ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-141471 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Molecular and cytogenetic analysis of mutations induced by a variety of genotoxic compounds at the heterozygous thymidine kinase locus in mouse lymphoma cells indicates that in vitro assay does indeed register the range of genetic lesions recently found in a wide variety of human tumors. The types and complexity of the induced lesions are reflected in mutant cell colony phenotype in a compound-specific fashion. These studies point to the use of appropriate in vitro mammalian mutagenesis assays as new model systems for dissecting the genetic lesions important to human carcinogenesis, and as a means of determining the potential for compounds to induce such lesions. (Copyright (c) 1992 Elsevier Science Publishers B.V.) |
Supplementary Notes |
Pub. in Mutation Research 270, n2 p201-209, 16 Nov 92. Prepared in cooperation with Florida State Univ., Tallahassee. Dept. of Biological Science, and Florida Inst. of Tech., Melbourne. Medical Genetics Lab. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
307031547 |
Origin |
NTIS |
Type |
CAT |