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RECORD NUMBER: 394 OF 1249

Main Title In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer.
Author Hozier, J. ; Applegate, M. ; Moore, M. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Florida State Univ., Tallahassee. Dept. of Biological Science. ;Florida Inst. of Tech., Melbourne. Medical Genetics Lab.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/448;
Stock Number PB93-141471
Additional Subjects Carcinogenesis ; Toxicology ; Mutagenicity tests ; DNA mutational analysis ; DNA probes ; Cultured cells ; Mice ; Genetic markers ; Genetic models ; In vitro analysis ; Reprints ;
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NTIS  PB93-141471 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract Molecular and cytogenetic analysis of mutations induced by a variety of genotoxic compounds at the heterozygous thymidine kinase locus in mouse lymphoma cells indicates that in vitro assay does indeed register the range of genetic lesions recently found in a wide variety of human tumors. The types and complexity of the induced lesions are reflected in mutant cell colony phenotype in a compound-specific fashion. These studies point to the use of appropriate in vitro mammalian mutagenesis assays as new model systems for dissecting the genetic lesions important to human carcinogenesis, and as a means of determining the potential for compounds to induce such lesions. (Copyright (c) 1992 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Mutation Research 270, n2 p201-209, 16 Nov 92. Prepared in cooperation with Florida State Univ., Tallahassee. Dept. of Biological Science, and Florida Inst. of Tech., Melbourne. Medical Genetics Lab.
NTIS Title Notes Journal article.
Title Annotations Reprint: In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer.
Category Codes 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 307031547
Origin NTIS
Type CAT