| Main Title |
Immunological Studies in Mice Following In utero Exposure to NiCl2. |
| Author |
Smialowicz, R. J. ;
Rogers, R. R. ;
Riddle, M. M. ;
Rowe, D. G. ;
Luebke, R. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/072; |
| Stock Number |
PB86-214863 |
| Additional Subjects |
Nickel chloride ;
Immunity ;
Toxicology ;
Bioassay ;
Pregnancy ;
Mice ;
Laboratory animals ;
Dosage ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-214863 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The effect that NiCl2 has on the development of immune function in mice was examined in the offspring of dams implanted with mini-osmotic pumps during pregnancy. Time bred C57BL/6J mice were implanted subcutaneously on day 5 of gestation with mini pumps which delivered a total dose of from 9.1 to 73.2 micrograms/g NiCl2. The pumps delivered NiCl2 to the dams through day 19 of gestation. At 8-10 weeks of age the offspring of NiCl2-dosed dams were evaluated for immune function. No consistent significant alterations were observed between control and treated offspring for the following: lymphoid organ or body weights; the lymphoproliferative response to B or T lymphocyte mitogens; the lymphoproliferative response to allogeneic spleen cells in the mixed lymphocyte reaction; the development of syngeneic tumors; or the primary antibody response to sheep red blood cells. Natural killer (NK) cell activity was reduced in offspring exposed to NiCl2 in utero; however, the biological relevance of these reductions is questionable because of the failure to demonstrate an increased susceptibility to the B16-F10 syngeneic tumor. The results indicate that under the conditions and doses employed it appears that NiCl2 does not adversely affect the developing immune system of the mouse. |
| Supplementary Notes |
Pub. in Toxicology 38, n3 p293-303 Mar 86. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Immunological Studies in Mice Following In utero Exposure to NiCl2. |
| PUB Date Free Form |
1986 |
| Category Codes |
6E; 6T; 57J; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
624112930 |
| Origin |
NTIS |
| Type |
CAT |
