Main Title |
Immune Function in Mice Exposed to the Adenosine Deaminase Inhibitor 2'-Deoxycoformycin During Immune System Development. |
Author |
Luebke, R. W. ;
Lawson, L. D. ;
Rogers, R. R. ;
Riddle, M. M. ;
Smialowicz, R. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/245; |
Stock Number |
PB88-177134 |
Additional Subjects |
Immunity ;
Mice ;
Exposure ;
Laboratory animals ;
Inhibitors ;
Reprints ;
Adenosine deaminase ;
Deoxycoformycin
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-177134 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Pregnant mice were administered 2'-deoxycoformycin (2dCF), a potent inhibitor of adensoine deaminase activity, by intraperitoneal injection on day 7 or 15 of gestation or from day 8-12 or 14-18 of gestation. A total dose of 0, 0.5 or 2.0 micrograms 2dCF/g of maternal body weight was given to all dams. In a separate study, pups born to nontreated dams were given 5 intraperitoneal injections totaling 0, 0.5, 2.0 or 4.0 micrograms 2dCF/g beginning at 4 weeks of age. Administered doses of 2dCF were at levels known to profoundly suppress adenosine deaminase levels in adult mice. Pups born to dams injected with 2dCF from day 14-18 all died within 48 h of birth whereas other injection schedules had no effect on birth rate or survival of pups. In utero 2dCF exposure had little effect on immune function in offspring. On the other hand, body, spleen and thymus weight, and splenic cellularity were decreased in weanling mice 24 h after the last injection of 4 micrograms/g 2dCF. Proliferative responses of splenocytes to T cell mitogens and alloantigens were likewise suppressed at both 2.0 and 4.0 micrograms/g 2dCF. |
Supplementary Notes |
Pub. in Immunopharmacology and Immunotoxicology, v9 n2-3p 149-161 1987. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Immune Function in Mice Exposed to the Adenosine Deaminase Inhibitor 2'-Deoxycoformycin During Immune System Development. |
PUB Date Free Form |
1987 |
Category Codes |
57J |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
812726797 |
Origin |
NTIS |
Type |
CAT |