| Main Title |
Acute Oral Toxicity (ld50) Study in Albino Mice Report with Cover Letter Dated 12/19/1977. |
| CORP Author |
Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-7749059 |
| Stock Number |
OTS0512867 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexachlorocyclopentadiene ;
Acute Toxicity ;
Mammals ;
Mice ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 77-47-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0512867 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
Acute oral toxicity was evaluated in groups of 5 male and 5 female Charles River CD-1 mice administered single doses of hexachlorocyclopentadiene as a solution in corn oil by oral gavage at levels of 21.5, 46.4, 100, 215, 464, 1000 and 2150 mg/kg of body weight. Mortality was observed in 1 female in the 46.4 mg/kg dose group, and all 10 animals in both the 1000 and 2150 mg/kg dose groups. The LD50 value was calculated to be 679 mg/kg (618-747 mg/kg 95% confidence limits) by the moving average method. Clinical observations included diarrhea, hypoactivity, decreased limb tone, ataxia, and ptosis. Gross necropsy findings were notreported. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801680 |
| Origin |
NTIS |
| Type |
CAT |
