| Main Title |
Evaluation of the Environmental Toxicants, Vinyl Chloride (VC) and Vinylidene Chloride (VDC), with Cover Letter dated 10/03/1995. |
| CORP Author |
National Inst. of Environmental Health Sciences, Research Triangle Park, NC.; Midwest Research Inst., Raleigh, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1995 |
| Report Number |
OTS-86960000161 |
| Stock Number |
OTS0558301 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Vinylidene chloride ;
Laboratory animals ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
Mice ;
CAS No 75-01-4 ;
CAS No 75-35-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558301 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
32p |
| Abstract |
This report summarizes the results of 9 months exposure to various levels of vinyl chloride (VC) and one level of vinylidene chloride (VDC) in rats and mice. At the end of 9 months exposure of rats to 50, 250, or 1,000 ppa VC, or 55 ppm VDC for 6 hours/day, 5 days/week, a number of adverse effects were found. Between the 33rd and 39th week, one male and three female rats exposed to VC died or were terminated. A number of tumors were found in these rats as well as in some of the rats terminated at the end of 9 months exposure to VC. Hemangiosarcomas were observed in liver, lung and adrenal gland of rats exposed to 250 or 1,000 ppm VC. The tumor incidence was higher in the rats exposed to 1,000 ppm VC than in rats exposed to 250 ppa VC. The body weight gain of female rats exposed to 1,000 pm VC was slightly depressed. Exposure to 55 ppm VDC slightly depressed the body weights of both male and female rats. At the end of 9 months exposure to VC or VDC, no adverse changes in clinical laboratory data occurred. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
29 Nov 1995 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500980 |
| Origin |
NTIS |
| Type |
CAT |
