| Main Title |
Evaluating the Toxicity of Urban Patterns of Oxidant Gases. 2. Effects in Mice from Chronic Exposure to Nitrogen Dioxide. |
| Author |
Miller, F. J. ;
Graham, J. A. ;
Raub, J. A. ;
Illing, J. W. ;
Menache, M. G. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/097; |
| Stock Number |
PB88-139969 |
| Additional Subjects |
Toxicology ;
Nitrogen ;
Urban areas ;
Exposure ;
Mice ;
Laboratory animals ;
Bioassay ;
Reprints ;
Air pollution effects
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-139969 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
The study reported herein evaluates the influence of a chronic exposure to an urban pattern of NO2 (continuous baseline exposure of 0.2 ppm on which were superimposed two 1-hr spikes of 0.8 ppm NO2, 5 days/wk) as compared to the baseline exposure to determine the contribution of the spikes to toxicity. Mice were exposed for up to 52 wk with interim examinations. Multivariate analysis of variance revealed a statistically significant treatment effect on infectivity (p=0.05) and pulmonary function (p=0.03) parameters. Infectivity mortality of mice in the spiked exposure regimen was significantly greater than that in either the NO2-background exposed mice or in control mice. Four of the pulmonary function variables exhibited the greatest differences among the treatment groups: end expiratory volume, vital capacity, respiratory system compliance, and multiple-breath nitrogen washout. Results from the pulmonary function analyses indicate that the spiked exposures to 0.8 ppm NO2 may have induced a subtle lesion. The chronic study results indicate that the presence of spikes of NO2 is contributing significantly to effects on antibacterial lung defenses and pulmonary function of mice. |
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v21 p99-112 1987. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Evaluating the Toxicity of Urban Patterns of Oxidant Gases. 2. Effects in Mice from Chronic Exposure to Nitrogen Dioxide. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Y; 68A |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
807117277 |
| Origin |
NTIS |
| Type |
CAT |
