| Main Title |
Effect of Phenobarbital on Diethylnitrosamine and Dimethylnitrosamine Induced Hepatocellular Tumors in Male B6C3F1 Mice. |
| Author |
Klaunig, J. E. ;
Weghorst, C. M. ;
Pereira, M. A. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/381; |
| Stock Number |
PB90-103169 |
| Additional Subjects |
Toxicity ;
Liver neoplasms ;
Phenobarbital ;
Carcinogens ;
Mice ;
Males ;
Body weight ;
Reprints ;
Diethylnitrosamine ;
Dimethylnitrosamine ;
Dose-response relationships ;
Drinking water ;
Organ weight
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-103169 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The effect of the type of carcinogen initiator on the ability of phenobarbital to promote hepatic tumor formation in 15-day-old initiated male B6C3F1 mice was evaluated. Fifteen day old male B6C3F1 mice were divided into 6 groups of 10 mice each. Groups 1 and 2 received a single intraperitoneal (ip) injection of diethylnitrosamine (DENA) (5 micro g/gbw). Groups 3 and 4 received a single ip injection of dimethylnitrosamine (DMNA) (5 micro g/gbw). Groups 5 and 6 received a single ip injection of saline. At weaning (28 days of age), mice in groups 2, 4, and 6 received phenobarbital (500 mg/ml) in their drinking water. Mice in groups 1, 3, and 5 received deionized drinking water. Drinking water treatment continued for 24 weeks at which time mice were sampled. At sampling, mice were examined for hepatic tumors by histology. Mice in Groups 5 (no treatment) and 6 (PB only) did not exhibit hepatic tumors. Groups 2 (DENA + PB) displayed a decrease in hepatic adenomas from that of Group 1 (DENA only) confirming previous observations. Treatment with DMNA and PB (Group 4) resulted in a significant increase in both hepatic adenoma incidence and number over that of DMNA only (Group 3) treated mice. (Copyright (c) 1988 Elsevier Scientific Publishers, Ireland Ltd.) |
| Supplementary Notes |
Pub. in Cancer Letters, v42 p133-139 Sep 88. Prepared in cooperation with Medical Coll. of Ohio at Toledo. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Phenobarbital on Diethylnitrosamine and Dimethylnitrosamine Induced Hepatocellular Tumors in Male B6C3F1 Mice. |
| Category Codes |
57Y; 57E; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
935215972 |
| Origin |
NTIS |
| Type |
CAT |
