Main Title |
Detection of Microwave Heating in 5-Hydroxytryptamine-Induced Hypothermic Mice. |
Author |
Smialowicz, R. J. ;
Riddle, M. M. ;
Brugnolotti, P. L. ;
Rogers, R. R. ;
Compton, K. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. |
Year Published |
1981 |
Report Number |
EPA-600/J-81-513; |
Stock Number |
PB82-154915 |
Additional Subjects |
Microwaves ;
Radiation effects ;
Detection ;
Hypothermia ;
Mice ;
Laboratory animals ;
Heating ;
Reprints ;
Tryptamine/hydroxy
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-154915 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
The intraperitoneal injection of 5-hydroxytryptamine (5-HT) in unrestrained and unanesthetized mice held at 22C causes a hypothermia which is maximal after approximately 15 minutes. When mice injected with 5-HT were held in a controlled environment of 22C and 50% relative humidity and exposed to microwaves (2450 MHz, cw) at 1 mW/sq cm for 15 minutes, significant increases were observed in the body temperature of these mice compared to 5-HT-treated sham-irradiated mice. The magnitude of the response was related to power density (10 > 5 > 1 mW/sq cm). Saline-injected mice exposed for 15 minutes at 10 mW/sq cm (specific absorption rate = 7.2 mW/g) showed no significant increase in body temperature compared to saline-injected sham-irradiated mice. The hypothermia induced by 5-HT in mice was also found to be affected by ambient temperature alone. Increases in ambient temperature above 22C, in the absence of microwaves, caused a concomitant increase in body temperature. By altering the thermoregulatory capacity of mice with 5-HT, subtle heating by microwaves was detected. These results indicate that the interpretation of microwave-induced biological effects observed in animals at comparable power and absorption levels should include a consideration of the thermogenic potential of microwave radiation. |
Supplementary Notes |
Pub. in Radiation Research 88, p108-117 1981. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Detection of Microwave Heating in 5-Hydroxytryptamine-Induced Hypothermic Mice. |
PUB Date Free Form |
3 Apr 81 |
Category Codes |
6R; 57V |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323810630 |
Origin |
NTIS |
Type |
CAT |