| Main Title |
Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury. |
| Author |
Goldey, E. S. ;
O'Callaghan, J. P. ;
Stanton, M. E. ;
Barone, S. ;
Crofton, K. M. ;
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Publisher |
cOct 94 |
| Year Published |
1994 |
| Report Number |
EPA-68-D2-0056; EPA/600/J-94/527; |
| Stock Number |
PB95-148896 |
| Additional Subjects |
Embryo development ;
Toxicity ;
Methylmercury compounds ;
Methylazoxymethanol acetate ;
Teratogens ;
Nervous system ;
Rats ;
Glial fibrillary acidic protein ;
Brain ;
Organ weight ;
Audiometry ;
Startle reaction ;
Motor activity ;
Cognition ;
Conditioned responses ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-148896 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
20p |
| Abstract |
Testing procedures for identification of potential developmental neurotoxicants were evaluated using two prototypical developmental neurotoxicants, methylazoxymethanol (MAM) and methylmercury (MeHg). A number of endpoints in the testing strategy were sensitive to the effects of prenatal exposure to MAM (30 mg/kg on Gestation Day (GD) 15): (1) MAM caused reduced neonatal body weights but did not affect viability or postnatal survivorship; (2) measurement of total and regional brain weight and histological analysis showed that a number of regions, the cortex and hippocampus in particular, were affected by MAM exposure; (3) an assay for glial fibrillary acidic protein (GFAP) showed that the concentration of this protein was significantly increased in the cortex and hippocampus of treated offspring; (4) a T-maze delayed-alternation procedure indicated that MAM-treated pups were slower in the acquisition phase of the task relative to control pups; (5) motor activity testing revealed hyperactivity in treated offspring that persisted into adulthood; and (6) acoustic startle procedures revealed reduced startle amplitudes in preweanlings. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v23 n3 p447-464 Oct 94. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
503415388 |
| Origin |
NTIS |
| Type |
CAT |
