| Main Title |
Flow Cytometric Analysis of the Mechanism of Methylmercury Cytotoxicity. |
| Author |
Zucker, R. M. ;
Elstein, K. H. ;
Easterling, R. E. ;
Massaro, E. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/353; |
| Stock Number |
PB91-163675 |
| Additional Subjects |
Methylmercury compounds ;
Toxicity ;
Fluorescence spectrometry ;
Cell survival ;
Flow cytometry ;
Dose-response relationships ;
Cell membrane ;
Erythro leukemia ;
Culture tumor cells ;
Cell cycle ;
Chromosomes ;
Mitosis ;
Computerized simulation ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-163675 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
The target and degree of methylmercury cytotoxicity are dose-dependent. Following 6 h exposure to 2.5 - 7.5 microMolar, methylmercury (MeHg) progressively inhibits DNA synthesis and induces chromosomal damage in murine erythroleukemic cells. However, following exposure to 10 - 50 microMolar MeHg, the plasma membrane/cytoplasm complex is grossly perturbed, cell cycle progression is blocked, and chromosomes appear in ring formations. These findings, together with those previously observed following organotin exposure, also suggest that severe and nonspecific toxicity may be a common endpoint of exposure to high levels of organometals. |
| Supplementary Notes |
Pub. in American Jnl. of Pathology, v137 n5 p1187-1198 Nov 90. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Flow Cytometric Analysis of the Mechanism of Methylmercury Cytotoxicity. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
113027493 |
| Origin |
NTIS |
| Type |
CAT |
