| Main Title |
Reproduction in F-344 Rats Exposed to Methyl Chloride by Inhalation for Two Generations with Cover Letter. |
| CORP Author |
Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
878214238 |
| Stock Number |
OTS-0206500 |
| Additional Subjects |
Toxicity ;
Laboratory animals ;
Rats ;
Toxic substances ;
Hazardous materials ;
Inhalation exposure ;
Testicular degeneration ;
Reproduction (Biology) ;
Methyl chloride ;
CAS No 79-87-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206500 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
318p |
| Abstract |
Male and female Fischer-344 rats were exposed to methyl chloride by inhalation (0, 150, 475 or 1500 ppm, 6 hours/day, 5 days/week, 40 males and 80 females per group). The only treatment related clinical signs were a 10 to 20% body weight gain depression (BWGD) in both males and females exposed to 1500 ppm at all weekly weighings after two weeks of exposure and a 5-7% BWGD in 475 ppm exposed animals after day 57. After 10 weeks the exposure schedule was changed to 6 hours/day 7 days/week and each male was mated to two exposed females. The mating period lasted two weeks and then ten males/group were necropsied. The only treatment related lesions found were severe testicular degeneration (10/10) and granulomas in the epididymis (3/10) in the 1500 ppm males. The remaining 30 males per group were then mated during a two week period with 60 unexposed females. The exposed females were continued on exposure from the start of mating to day 18 of gestation (6 hours/day, 7 days/week). The females were not exposed from gestation day 18 to postnatal day 4, but exposure (6 hours/ day, 7 days/week) of these females was resumed from postnatal day 4 to postnatal day 28. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
20 Apr 1984 |
| Category Codes |
57Y |
| NTIS Prices |
PC A15/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019000220 |
| Origin |
NTIS |
| Type |
CAT |
