| Main Title |
Rodent Whole-Embryo Culture as a Teratogen Screening Method (Journal Version). |
| Author |
Kitchin, K. T. ;
Schmid, B. P. ;
Sanyal, M. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Yale Univ., New Haven, CT. School of Medicine. |
| Publisher |
c1986 |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/491; |
| Stock Number |
PB89-104863 |
| Additional Subjects |
Teratogens ;
Toxicology ;
Drug screening ;
Methodology ;
Embryo ;
Laboratory animals ;
Tissue culture ;
Fetal development ;
Postimplantation phase ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-104863 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
In vitro rodent whole embryo culture offers a wholistic system in which extremely rapid cell division and specific time-related morphogenic events occur. Because in vitro development so closely parallels that occurring in vivo, the in vitro embryo culture system appears to be particularly relevant in the detection of teratogenic and embryotoxic compounds. Correlation between the in vitro screen and the published results of in vivo embryo toxicology and teratology studies has been very good. There is a high correlation (r=0.97) between the concentration of teratogenic agents which cause adverse effects in vitro and the in vivo teratogenic dose of these compounds. |
| Supplementary Notes |
Pub. in Methods and Findings in Experimental Clinical Pharmacology, v8 p291-301 1986. Prepared in cooperation with Yale Univ., New Haven, CT. School of Medicine. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Rodent Whole-Embryo Culture as a Teratogen Screening Method (Journal Version). |
| Category Codes |
57Y; 57H; 44G; 68G |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
833026996 |
| Origin |
NTIS |
| Type |
CAT |
