| Main Title |
Augmentation of Sulfate Ion Absorption from the Rate Lung by Heavy Metals. |
| Author |
Charles, Jeffrey M. ;
Gardner, Donald E. ;
Coffin, David L. ;
Menzel., Daniel B. ;
|
| CORP Author |
Duke Univ. Medical Center, Durham, N.C.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Year Published |
1977 |
| Report Number |
EPA-68-02-2436; EPA/600/J-77/086; |
| Stock Number |
PB-278 585 |
| Additional Subjects |
Absorption(Biology) ;
Sulfates ;
Lung ;
Metals ;
Air pollution ;
Contaminants ;
Interactions ;
Respiration ;
pH ;
Ions ;
Absorption(Biology) ;
Rats ;
Laboratory animals ;
Reprints ;
Heavy metals ;
Particulates
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 585 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The effect of heavy metal cations in enhancing the absorption of sulfate ions from the airways of the rat lung was studied. The cations investigated included Cd(2+), Co(2+), Hg(2+), Ni(2+), Fe(3+), Mn(2+), and Zn(2+). The cations exhibited differing efficacies. Co(2+), Hg(2+), Cd(2+), and Ni(2+) produced maximal effect at 0.1 nmol/lung, while Fe(3+) and Zn(2+) were the least effective, reaching maximal effect at 10.0 nmol/lung. An exception was Mn(2+), which did not alter absorption. Hydrogen ion concentrations departing from physiological pH values (4.4-9.4) enhanced sulfate ion absorption. Exposure of rats to a NiCl2 aerosol of 480 micrograms of Ni/cu m for 2 hr prior to the determination of sulfate ion absorption led to a 12.0 plus or minus 2.7% enhancement of absorption. These results suggest a possible correlation between the irritant potential associated with inhalation of a specific sulfate salt and the rate at which sulfate ions are absorbed from the lung. (Copyright (c) 1977 by Academic Press, Inc.) |
| Availability Notes |
Pub. in Toxicology and Applied Pharmacology 42, p531-438 1977. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Augmentation of Sulfate Ion Absorption from the Rate Lung by Heavy Metals. |
| PUB Date Free Form |
16 Jul 77 |
| Category Codes |
6T; 6P; 57Y; 57S; 68G; 68A |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323736891 |
| Origin |
NTIS |
| Type |
CAT |
