Main Title |
Importance of Experimenter-Blind Procedure in Neurotoxicology (Mini-Review). |
Author |
Benignus, V. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/093; |
Stock Number |
PB93-175628 |
Additional Subjects |
Toxicology ;
Experimental data ;
Air pollution effects(Humans) ;
Double-blind method ;
Statistical analysis ;
Neurotoxins ;
Carbon monoxide ;
Exposure ;
Tables(Data) ;
Reprints ;
Single-blind method ;
Meta-analysis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-175628 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
The importance of having the investigator blind to the experimental condition of a human subject was demonstrated using meta analysis of 43 reports of the effects of carbon monoxide (CO) on behavior. It was shown that 75% of single-blind studies found significant CO effects as opposed to only 26% of double-blind studies (difference was significant, p < 0.005). It was also not possible to show that the difference could have been due to different CO exposure levels, different statistical practices, or different study group sizes. The failure to follow double-blind procedure has been partly responsible for disagreement about the effects of CO reported in the literature. Investigator blinding is also important in laboratory animal research. (Copyright (c) 1993 Pergamon Press Ltd.). |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v15 n1 p45-49 1993. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Psychology. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Importance of Experimenter-Blind Procedure in Neurotoxicology (Mini-Review). |
Category Codes |
57Y; 57E; 57H; 68A; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
316130691 |
Origin |
NTIS |
Type |
CAT |