Main Title |
Effects of Metals on Pulmonary Defense Mechanisms Against Infectious Disease. |
Author |
Graham, J. A. ;
Gardner., D. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div. |
Year Published |
1977 |
Report Number |
EPA/600/J-77/096; |
Stock Number |
PB-278 569 |
Additional Subjects |
Meetings ;
Toxicity ;
Metals ;
Immunity ;
Lung ;
Respiratory diseases ;
Infectious diseases ;
Immunology ;
Toxicology ;
Alveolar pulmonis ;
Phagocytes ;
Bacteria ;
Air pollution ;
Macrophages ;
Immunosuppression ;
Air pollution effects(Humans)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-278 569 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
The respiratory system under normal conditions has the ability to maintain sterility of the deep lung even when large numbers of microbes are deposited under laboratory conditions. A number of mechanisms have been shown to be responsible for this defense of the lung, namely, mechanical clearance via the mucociliary escalator, biological clearance mediated through the alveolar macrophage (AM), and associated cellular and humoral immunological events. The adverse effects of numerous gaseous pollutants on these pulmonary defense mechanisms against infectious disease have long been recognized. Recently, researchers have begun to investigate the propensity of trace metals for causing similar effects. |
Supplementary Notes |
Pub. in Proceedings of the Annual Conference on Environmental Toxicology (7th), Aerospace Medical Research Lab., Wright-Patterson AFB, Ohio, 13-15 Oct 76 (Paper n8, rept. no. AMRL-TR-76-125) p171-187 Apr 77. |
NTIS Title Notes |
Journal article. |
PUB Date Free Form |
Apr 77 |
Category Codes |
6T; 6F; 57Y; 57J; 68G; 68A |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323736819 |
Origin |
NTIS |
Type |
CAT |