||Computerized Assessment of Human Neurotoxicity: Sensitivity to Nitrous Oxide Exposure.
Greenberg, B. D. ;
Moore, P. A. ;
Letz, R. ;
Baker, E. L. ;
||Harvard School of Public Health, Boston, MA.;Health Effects Research Lab., Research Triangle Park, NC.
Nitrous oxide ;
Medical computer applications
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The authors recently developed a flexible, portable, computer based neurobehavioral evaluation system (NES) to standardize data collection in epidemiologic field studies of individuals at risk for neurobehavioral toxicity. The current study was performed to examine the system's sensitivity to subtle neurobehavioral impairment induced pharmacologically in normal subjects. Twelve men 18 to 36 years old were tested with the NES three times, in an initial training session followed by separate drug and control sessions in randomized order. During drug sessions subjects received a combination of 20% nitrous oxide and 80% oxygen through a nasal mask. In control sessions subjects received 100% oxygen. Nine NES tests evaluating psychomotor performance, visuospatial ability, memory, and mood were administered in approximately 40 minutes. Nitrous oxide exposure impaired performance on three tests: continuous performance, symbol-digit substitution, and finger tapping. Another test, pattern memory, showed a trend toward impairment, while the remainder were not affected by the drug. These data are consistent with previous reports that the threshold effect of nitrous oxide is a decrement in psychomotor speed.
||Pub. in Clinical Pharmacology and Therapeutics, v38 n6 p656-660 Dec 85. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Computerized Assessment of Human Neurotoxicity: Sensitivity to Nitrous Oxide Exposure.
|PUB Date Free Form
||6T; 9B; 57Y; 62
||PC A02/MF A01