| Main Title |
Deposition Patterns of Ragweed Pollen in the Human Respiratory Tract. |
| Author |
Martonen, T. B. ;
O'Rourke, M. K. ;
|
| CORP Author |
Arizona Univ., Tucson. Div. of Respiratory Sciences.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA-R-811806; EPA/600/J-92/312; |
| Stock Number |
PB92-227537 |
| Additional Subjects |
Respiratory system ;
Toxicology ;
Allergens ;
Humans ;
Respiration ;
Mathematical models ;
Reprints ;
Ragweed pollen
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-227537 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Inhaled particle deposition sites must be identified to effectively treat human airway diseases. The authors have determined distribution patterns of a selected aeroallergen, ragweed pollen, among human extrathoracic (ET: i.e., oro-nasopharyngeal) regions and the lung. A predictive model validated by inhalation exposure data from human subjects was utilized. Deposition locations were primarily functions of (1) ragweed particle parameters (size, 14-20 micrometers; shape, spherical; and density, 1.14 g cu cm) and (2) mode of breathing. In the general population, two styles of inhalation are prevalent: normal augmentors (NAs), and mouth breathers (MBs), their clinical definitions are based on intra-ET airflow divisions. For a NA-mode breathing, sedentary (10 L/min) adult, 88% of inhaled ragweed pollen was removed by the ET compartment and 7.0% collected within the lung. For a MB, the respective deposition efficiencies were 68% and 25%. To apply the model, they used a daily springtime ragweed pollen concentration of 300 grains/cu m and an exposure time of 0.5 hour to calculate actual doses for the respiratory system. Under the stipulated conditions, a MB would inhale 45 pollen grains per day and 8 would be deposited in the lung; the value is 3 grains for a NA. Frequently, individuals with impaired respiratory functions are MBs in whom such pollen deposits are likely contributors to airway disease. |
| Supplementary Notes |
Pub. in GRANA, v30 n1 p82-86 Jun 91. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Deposition Patterns of Ragweed Pollen in the Human Respiratory Tract. |
| Category Codes |
57Y; 57J |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
229734124 |
| Origin |
NTIS |
| Type |
CAT |
