| Main Title |
Dehp Metabolism Studies Protocol Ii Species Differences in the Metabolism of a Single Oral Dose of Dehp. |
| CORP Author |
Bio-Dynamics Research and Development Corp., Eugene, OR.; Hooker Chemical Corp., Burlington, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8426135 |
| Stock Number |
OTS0508494 |
| Additional Subjects |
Toxicology ;
Health effects ;
Benzylbutyl Phthalate ;
Pharmaco Kinetics ;
Mammals ;
Monkeys ;
Oral ;
Gavage ;
Rats ;
Mice ;
Toxic substances ;
Laboratory animals ;
CAS No 117-81-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0508494 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
121p |
| Abstract |
Pharmacokinetics of di(2-ethylhexyl)phthalate (DEHP) were evaluated in 3 male Cynomolgus monkeys, 5 male Fischer-344 rats, and 5 groups of male B6C3F1 mice (5/group) fed a single nominal dose of 100 mg 14-C-DEHP/kg bw by gavage. All species excreted approximately 30-40% of the dose via the urinary route, primarily during the first 12 hours for rats and mice, and during the first 24 hours for monkeys. Only minimal excretion (ca. 5% or less of the dose) occurred after 24 hours in all species. All species excreted approximately 50% of the dose via the fecal route, primarily during the first 24 hours for rats and mice, and during the first 48 hours for monkeys. DEHP equivalents were detectable in some tissues in all species. The mean concentrations detected, with the exception of monkey liver and rat intestinal contents, were less than 1 ug/g. The highest concentrations were detected in the liver, intestinal contents, and fat for monkeys, rats, and mice, respectively. Total recoveries of the 14C-DEHP radioactivity administered were 79, 87, and 90% for monkeys, rats, and mice, respectively. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Hooker Chemical Corp., Burlington, NJ. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801300 |
| Origin |
NTIS |
| Type |
CAT |
