| Main Title |
Cumene (isopropyl Benzene): Thirteen-week Vapor Inhalation Study in Rats with Attachments and Cover Letter Dated 09/25/1991. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
86-910001018 |
| Stock Number |
OTS0532654 |
| Additional Subjects |
Toxicology ;
Health effects ;
Cumene (98-82-8) ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 98-82-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0532654 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
569p |
| Abstract |
Cumene (CAS No. 98-82-8) was evaluated for subchronic toxicity. The test substance was administered by inhalation to rats (15/sex/group) 6 hours/day, 5 days/week for 13 weeks at concentrations of 0, 50, 100, 500, and 1,200 ppm. No mortalities were observed, and there were no exposure-related cataract formations, neurotoxic responses, body weight changes, or gross pathologic findings. All treated females and the males of the 2 highest exposure groups had swollen periocular tissue. Absolute and relative liver weights were increased in both sexes at 1,200 ppm and in females at 500 ppm. There was an increase in the absolute and relative lung and adrenal gland weights in females of the 1,200 ppm group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1991 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A25/MF A25 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803160 |
| Origin |
NTIS |
| Type |
CAT |
