| Main Title |
Usepa Status Report: 2-ethylhexanol with Cover Letter. |
| CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
8EHQ-0390-0910S |
| Stock Number |
OTS0524015-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-ethylhexanol ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 104-76-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0524015-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
2-Ethylhexanol (CAS No. 104-76-7) was administered to groups of 10 rats by gavage at doses of 130, 650, or 1300 mg/kg/day on gestation days 6 through 15. Control groups were also dosed with distilled water or distilled water with Cremophor EL. Rats were sacrificed and examined along with their fetuses on day 20. At the highest dose level 6 rats died during the treatment period, food consumption and body weight gains were reduced and there were clinical signs of severe toxicity including postural changes and apathy. The deceased animals showed discoloration changes in the liver. Increased resorptions and postimplantation losses and decreased fetal weights were evident in the high dose groups as were increased malformations, including soft tissue variations and skeletal malformations, variations and retardations. At the middle dose there were only minimal signs of maternal toxicity (piloerection) and marginally reduced fetal weights and increased fetal skeletal variations and retardations. No maternal or fetal effects were noted in the low dose group. The authors conclude that teratogenicity is apparent only at levels which show severe maternal toxicity. This EPA status report includes only the summary of the study. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802510 |
| Origin |
NTIS |
| Type |
CAT |
