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RECORD NUMBER: 2057 OF 2096| Main Title | Two-week Pilot Inhalation Toxicity Study of Cumene Vapors in Rats (Final Report) with Attachments, Appendices and Cover Letter Dated 08/15/1989. | |||||||||||
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| CORP Author | Chevron Research Co., Richmond, CA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1989 | |||||||||||
| Report Number | 86-890001427 | |||||||||||
| Stock Number | OTS0521042 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Cumene (98-82-8) ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 98-82-8 | |||||||||||
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| Collation | 287p | |||||||||||
| Abstract | Cumene (CAS No. 98-82-8) was evaluated for subchronic toxicity. The test substance was administered by inhalation to rats (10/sex/group) 6 hours/day, 5 days/week at 0, 250, 750, 1,500, and 2,000 ppm for 1-2 days. At this time, it was determined that there was excessive toxicity (ataxia, abnormal respiration, ocular discharge, decreased motor activity, and collapse) in the highest exposure groups, and the concentrations were changed to 0, 250, 500, 1,000 and 1,200 ppm for the remainder of the 2- week study duration. As compared to controls, both sexes of rats in the 2,000/1,200 and 1,500/1,000 ppm groups had ataxia, ocular and anogenital discharge, hypo and/or hyperactivity, anemia, decreased food consumption and body weights, increased liver weights; females of these groups had increased serum chemistry levels (cholesterol, protein, albumin, and triglycerides) and adrenal weights, and males had increased kidney weights. Increased liver weights and ocular and anogenital discharges in males and females, increased kidney weights in males, and decreased food consumption in females were noted in the 750/500 group as compared to controls. The NOEL in this study was 250 ppm. | |||||||||||
| Supplementary Notes | The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Availability Notes | Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. | |||||||||||
| PUB Date Free Form | 1989 | |||||||||||
| Category Codes | 57Y; 57U; 68G; 99; 44G | |||||||||||
| NTIS Prices | PC A14/MF A14 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 028802440 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |