| Main Title |
Twenty-eight-day Repeated Dose Dermal Toxicity Study of Hexamethyldisiloxane in Rats with Cover Letter dated 04/20/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001823 |
| Stock Number |
OTS0572811 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexamethyldisiloxane ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 107-46-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572811 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
84p |
| Abstract |
This study evaluated the potential 28 day dermal toxicity of methyl disiloxane fluid. The test substance was applied to the skin of Sprague Dawley rats (10 male and 10 female per dose group) at doses of 0, 100, 500 or 1000 mg/kg/day with nonocclusive covering. The material was applied approximately 6 hours per day 5 days per week for 28 days. The animals were observed daily for general appearance, untoward effects, signs of local or systemic toxicity, and death. After 28 days the animals were sacrificed and examined for changes in hematology, clinical chemistry and organ weight. Gross necropsy and histopathological examinations were also conducted. No deaths, signs of toxicity or untoward effects were reported. No treatment related changes were reported in hematological, clinical chemistry or histopathological parameters. Statistically significant decreases in body weight gains were reported in the high dose males in weeks 3 and 4. However, significant decreases in food consumption was also reported at these times. Significant decreases in absolute liver weight were also seen in this group. Histopathology did not demonstrate any cause for these decreases. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804340 |
| Origin |
NTIS |
| Type |
CAT |
