| Main Title |
Tributyl Phosphate: Skin Sensitization Study in Guinea Pifs (Final Report) with Cover Letter Dated 03/26/1990. |
| CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-9021192 |
| Stock Number |
OTS0528314 |
| Additional Subjects |
Toxicology ;
Health effects ;
Tributyl Phosphate ;
Primary Dermal Sensitization ;
Mammals ;
Guinea Pigs ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 126-73-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0528314 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
Tributyl phosphate was tested for skin sensitization in Hartley guinea pigs (10/sex) exposed dermally to 0.30 ml of a 10% (w/v) mixture in mineral oil for 6 hours, once weekly for 3 weeks. An additional 10 animals (vehicle control group) received a similar treatment with mineral oil only. Fourteen days after the third induction treatment, the treated animals were challenged with the test material at a virgin site; an additional 10 animals, not previously exposed, received a similar challenge exposure with the test compound. The vehicle control group was challenged with mineral oil. Animals were examined for erythema at 24 and 48 hours after the challenge exposure. The treatment, challenge control, and vehicle control groups did not display sensitizing reactions (erythema/ eschar and edema scores of 0). Tributyl phosphate was non-sensitizing after dermal application in guinea pigs. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803030 |
| Origin |
NTIS |
| Type |
CAT |
