| Main Title |
Toxicology of Fine Chemicals: the Acute 4-hour Inhalation Lc50 of 1,3-dichloropropane in Rats with Cover Letter dated 04/25/1986. |
| CORP Author |
Shell Oil Co., Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216428 |
| Stock Number |
OTS0510356 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
3-dichloropropane (142-28-9) ;
Acute Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 142-28-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510356 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
An acute inhalation toxicity study was conducted with groups of male and female albino Wistar rats (5/sex/group) receiving a single whole body exposure to 1,3-dichloropropane in a dynamic air flow chamber for 4 hours. Groups of animals were exposed to the test material at mean analytical concentrations of 29, 34, 42, 47 or 56mg/l, resulting in the following cumulative mortality data (no. animals dead/no. animals tested): 2/10, 4/10, 6/10, 9/10 and 10/10, respectively. Most of the deaths occurred on day 1 of the 14 day observation period. All animals were observed with increased respiratory rates within two hours of the start of the exposure. Gross necropsy of surviving rats revealed pale lower margins of the diaphragmatic lobes of the lungs. However, microscopic examination revealed no histopathological alterations. The acute inhalation LC50 of 1,3-dichloropropane was determined by Probit analysis to be 36mg/l (95% fiducial limits of 32 to 40mg/l). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801530 |
| Origin |
NTIS |
| Type |
CAT |
