| Main Title |
Toxicity and Potential Dangers of Methyl Methacrylate (MONOMER) with Attachment and Cover Sheet Dated 06/12/1989. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86-890000818 |
| Stock Number |
OTS0520934 |
| Additional Subjects |
Toxicology ;
Health effects ;
Methyl Methacrylate (80-62-6) ;
Acute Toxicity ;
Mammals ;
Rats ;
Parenteral ;
Subcutaneous ;
Cats ;
Rabbits ;
Biochemistry ;
Oral ;
Gavage ;
Subchronic Toxicity ;
Dermal ;
Inhalation ;
Mice ;
Dogs ;
Toxic substances ;
Laboratory animals ;
CAS No 80-62-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0520934 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
45p |
| Abstract |
Single subcutaneous injections of rats with methyl methacrylate at a dose of 0.001 cc/g bw caused mild depression, while 0.007 cc/g led to irregular respiration, asphyxia, coma and death. Cats and rabbits subcutaneously injected with doses of 0.0025 cc/g and above showed dose-related depression, irregular respiration, blood in the urine, asphyxia, coma; at doses of 0.0035 and 0.005 cc/g, death ensued. The minimal fatal dose (killing 50 to 90%) for rats administered single doses of methyl methacrylate by gavage was 0.009 to 0.01 cc/g, while 2 doses of 3 cc/g were lethal to cats. Repeated oral doses to rats of 0.005 cc/g every other day for 70 days caused reduced weight gain, blood in the urine, and increased numbers of deaths. Dermal exposure of rats to 1 cc test compound/day for 10 weeks led to edema in all rats, while a repeat exposure on 'hot summer days' caused only temporary local irritation. Single 8-hour inhalation exposure of rats to 30 mg/L of test compound killed approximately 70%, while 11.2 mg/L caused only slight irritation of the upper respiratory tract. Inhalation exposure to 33.5 mg/L led to age-related increased mortality among rats tested at age 12 days (no deaths), 6 weeks (3/5 deaths), or when fully grown (100% mortality). Rats, cats and rabbits exposed to 4.95 mg/L for 18 days, 6 hours/day, by inhalation showed contracted urinary bladders and blood in the urine. Rats and mice exposed via inhalation in constant darkness suffered less mortality than those exposed for 2 to 3 hours of direct sunlight/day. Continuous inhalation exposure of rats (3.5 mg/L for 22 hours), cats and rabbits (15 mg/L for 5 days) was fatal to 1 cat and led to blood in the urine of rats and rabbits, but not the cats. Inhalation (40 mg/L) or subcutaneous injection (2.5 cc/kg bw) caused decreased respiratory rate in both dogs and rabbits without altering blood pressure. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802310 |
| Origin |
NTIS |
| Type |
CAT |
