| Main Title |
Teratology Studies in Rats & Rabbits with Oleylamine and Range-finidng Teratology Studies in Rats & Rabbits with Oleylamine (Final Reports) with Cover Letter Dated 11/28/1989. |
| CORP Author |
Springborn Labs., Inc., Wareham, MA.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8984324 |
| Stock Number |
OTS0525408 |
| Additional Subjects |
Toxicology ;
Health effects ;
Oleylamine ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Oral ;
Gavage ;
Rats ;
Toxic substances ;
Laboratory animals ;
CAS No 112-90-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525408 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
845p |
| Abstract |
Oleylamine was evaluated for potential teratogenicity to mated female rats (28/group) administered oral doses of 0, 10, 40, or 80 mg/kg/day by gavage in corn oil on gestation days 6 through 15. Doses were selected by means of a range-finding study. No treatment-related mortalities occurred. Clinical signs were observed in the 40 (salivation) and 80 mg/kg/day (salivation and rales) groups, along with dose-dependent body weight losses, reduced weight gain, and decreased food consumption at these levels. No evidence of embryotoxicity, fetotoxicity, or teratogenicity was noted. A developmental study was conducted in rabbits (22 inseminated females/group) orally administered 0, 3, 10, or 30 mg/kg/day by gavage in corn oil on gestation days 6 through 18. Doses were determined in a range-finding study. Dose- related maternal toxicity (2 deaths in high-dose group, 1 female from each treatment group aborted prior to scheduled sacrifice, rales, irritation of mouth area, decreased body weight, weight gain, and food consumption) was noted at 10 mg/kg/day and above. No signs of embryotoxicity, fetotoxicity or teratogenicity were noted. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802640 |
| Origin |
NTIS |
| Type |
CAT |
