| Main Title |
Support: TSCA Health and Safety Study Cover Sheet with Preliminary Results from 4-Week Inhalation Toxicity Study of Cyclopropanemethanol in Rats, with Cover Letter dated 05/171/1998. |
| CORP Author |
Eastman Kodak Co., Rochester, NY.; Eastman Chemical Co., Kingston, TN.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
8EHQ-1598-13706 |
| Stock Number |
OTS0558578-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
CAS No 2516-33-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558578-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
In this study, male and female Sprague-Dawley rats were exposed to nominal concentrations of 0, 0.1, 0.3, or 1.0 mg/1 of CPMO for 6 hours per day, 5 days per week for 4 weeks. Animals were observed during and after exposure and daily on non-exposure days. Body weights and feed consumption were measured weekly. Minimal signs of toxicity such as reduced activity during exposure, reduced feces, and porphyrin discharge from the nose were obsesved in animals exposed to 1.0 mg/1. Porphyrin discharge from the nose was also seen in mid-dose female rats. No other unusual or remarkable effects were seen at the lower concentrations. After 4 weeks of exposure, animals were fasted and sacrificed. Blood was collected and analyzed for clinical chemistry and hematology. White blood cell count was decreased in the male and female high-dose animals. Red blood cell count, hematocrit, and hemoglobin were reduced in the high-dose females. Prothrombin time was increased in the male and female high- dose animals. Blood urea nitrogen (BUN) was increased in the high-dose treatment groups. Glucose was increased in the mid- and high-dose males. Triglycerides were increased in the high-dose females. Cholesterol was decreased in all male test groups. Mean relative (to body weight) heart weights for female rats exposed to 0.1 and 1.0 mg/1 were significantly higher than for the control groups. Liver weights for the mid- and high-dose male group, and for all treated female groups were significantly higher than for the control group. Testes and epididymides weights were significantly decreased in the high-dose males. Histopathologic examinations indicated that the target organs were liver and heart (all animals), testes and epididymides (males) and sternal bone marrow (females). Lesions in the heart included myocarditis, muscle fiber vacuolation, and muscle fiber degeneration. These heart lesions were observed at all exposure levels for both male and female rats. Lesions in the liver included hepatocellular eytoplasmic vacuolation, which was observed at all exposure levels for both males and females. Lesions in the testes were spermatid degeneration, which was seen only in the 1.0 mg/1 male group. Seminiferous tubule degeneration was also seen in the high dose male group. There was a mild decrease in cellularity within the sternal bone marrow in the 1.0 mg/1 female group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
14 May 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A01/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501550 |
| Origin |
NTIS |
| Type |
CAT |
