| Main Title |
Support: Styrene-104 Week Repeat Dose Inhalation Combined Toxicity/Carcinogenicity Study in Mice with Cover Letter dated 07/22/1998. |
| CORP Author |
Huntingdon Life Sceinces, Ltd.; Styrene Information and Research Center, Inc.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
8EHQ-0798-13707 |
| Stock Number |
OTS0558579-2 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Chronic toxicity ;
Combined chronic toxicity ;
Combined chronic carcinogenicity ;
Mammals ;
Mice ;
Inhalation ;
CAS No 100-42-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558579-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
369p |
| Abstract |
This study was performed to assess the chronic toxicity and carcinogenic potential of styrene, administered by whole-body inhalation exposure to CD-1 mice over a period of 2 years. Exposure was carried out for 6 hours a day, 5 days a week at exposure levels of 0, 20, 40, 80 or 160 ppm. The initial group size was 70 mice of each sex, of which 10 mice of each sex were allocated for sacrifice following 52 and 78 weeks of exposure. Due to increased mortality in female control mice terminal sacrifice took place during Week 98. Male mice were sacrificed as scheduled following 104 weeks of exposure. Samples of blood were removed from mice immediately after a typical exposure (Week 74) and analysed for styrene monomer and styrene oxide. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
23 Jul 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A17/MF A17 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501560 |
| Origin |
NTIS |
| Type |
CAT |
