| Main Title |
Support: Letter from Wacker Silicones Corp. to USEPA Submitting Summary of an Acute Oral Toxicity Test in Rats of Calcium Acetylacetonate, dated 08/20/1992. (Sanitized). |
| CORP Author |
Wacker Silicones Corp., Adrian, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-5996S |
| Stock Number |
OTS0537623-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
2 ;
4-pentanedoine ;
Ion(1-) ;
Calcium ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Neurotoxicity ;
Acute toxicity ;
CAS No 19372-44-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0537623-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The new substance was tested to determine the median lethal dose when given to male and female rats by a single oral administration of 1000 mg/kg and 1500 mg/kg. The acute oral LD50 was determined to be 1250 mg/kg for male rats and 1417 mg/kg for female rats. Eight of the 20 rats died prior to study termination. Some clinical signs noted included tremors, poor physical condition and convulsions. Gross necropsy finding on the dead animals showed redness and swelling of the gastric mucous membrane, lung and liver congestion, urinary retention and discoloration of the renal pelvis and spleen. Animals sacrificed at the 14 day termination period showed no treatment related effects either in body weight gain or in gross nerospy findings. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
1 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
100700240 |
| Origin |
NTIS |
| Type |
CAT |
