| Main Title |
Support: Final Report, HPA: One Generation Reproduction Study in Rats (Corrected, Complete Copy), with Cover Letter dated 09/02/1997. |
| CORP Author |
Inveresk Research International Ltd., Edinburgh (Scotland).; FMC Corp., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1997 |
| Report Number |
8EHQ-0997-13549 |
| Stock Number |
OTS0558423-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Hydroxyphosphonoacetic acid ;
Laboratory animals ;
Subchronic toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Reproduction/fertility effects ;
Combined teratogenicity/reproductive effects ;
CAS No 23783-26-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558423-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
314p |
| Abstract |
The test material Hydroxyphosphonoacetic acid (HPA) was accepted from FMC Corporation, New Jersey, USA to evaluate the effects on general reproductive performance when the test material was administered through a complete reproductive cycle. Sprague-Dawley rats were randomised into 6 groups, each containing 24 males and 24 females. The animals were dosed orally by gavage, at a constant dose volume of 10 ml/kg body weight once daily, at the specific dose levels. Both sexes were dosed for 10 weeks prior to mating, and then throughout the mating, gestation and lactation periods. The offspring were monitored for survival and growth up to the age of weaning. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
9 Sep 1997 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A15/MF A15 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501150 |
| Origin |
NTIS |
| Type |
CAT |
