| Main Title |
Acute Skin Absorption Ld50 Testing on Rabbits. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86-870001092 |
| Stock Number |
OTS0514995 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexanedinitrile (111-69-3) ;
Acute Toxicity ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 111-69-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0514995 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
3p |
| Abstract |
Acute dermal toxicity was evaluated in groups of 6 male New Zealand White rabbits receiving single occluded applications of hexanedinitrile at dose levels of 1000, 1250, 1350, 1500, 2000, and 4000 mg/kg of body weight. The test article was held in contact with the intact skin for a period of 24 hours. Mortality was observed within 14 days of treatment in 3-4 animals at dose levels 1350 to 4000 mg/kg; the LD50 was calculated to be 2134 mg/kg of body weight. Clinical observations included gasping, diarrhea and lethargy. Intermittent weight loss was noted at all levels. Gross necropsy was not reported. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A01/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801980 |
| Origin |
NTIS |
| Type |
CAT |
