| Main Title |
Acute Oral Toxicity to Rats of Hexachlorocyclopentadiene with Cover Letter 11/25/1986. |
| CORP Author |
Huntingdon Research Centre PLC (England).; Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86870000040 |
| Stock Number |
OTS0513386 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexachlorocyclopentadiene (77-47-4) ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 77-47-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0513386 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Acute oral toxicity was evaluated in groups of 5 male and 5 female Sprague-Dawley rats administered hexachlorocyclopentadiene in corn oil by gavage at a level of 1.26, 1.60 or 2.00 g/kg. Mortality was observed in 1 male and 2 females in the 1.26 g/kg group, 3 males and 5 females in the 1.60 g/kg group and in all animals in the 2.00 g/kg group. The LD50 was determined to be 1.4 (1.2-1.5) g/kg for males and females combined, 1.5 (1.3-1.7) g/kg for males only and 1.3 (1.0-1.5) g/kg for females only. Clinical observations included piloerection, abnormal posture and gait, lethargy, decreased respiration, ptosis, pallor of the extremities, diarrhea and prostration. Necropsy revealed nothing unusual. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Velsicol Chemical Corp., Chicago, IL. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801780 |
| Origin |
NTIS |
| Type |
CAT |
