| Main Title |
Acute Oral Toxicity (up/down Method) Report with Cover Letter Dated 02/09/1987. |
| CORP Author |
Hazleton Labs., Inc., Vienna, VA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86870000160 |
| Stock Number |
OTS0513345 |
| Additional Subjects |
Toxicology ;
Health effects ;
Isopropanol (67-63-0) ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 67-63-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0513345 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
108p |
| Abstract |
Acute oral toxicity was evaluated in groups of 1 to 3 male and 1 to 4 female fasted albino Sprague-Dawley rats administered undiluted isopropanol by gavage at a level of 4.5, 5.8, 7.5 or 9.8 g/kg for males and 3.5, 4.5, 5.8 or 7.5 g/kg for females. Mortality was observed in 2/3 males in the 5.8 g/kg group, 3/3 in the 7.5 g/kg group and 1/1 in the 9.8 g/kg group and in 2/4 females in the 4.5 g/kg group, 2/2 in the 5.8 g/kg group and in 1/1 in the 7.5 g/kg group. The LD50 value was determined to be 5.3 g/kg for male rats and 4.5 g/kg for female rats. Clinical observations included soft stools, diarrhea, ataxia, decreased limb tone, hypoactivity, hypothermia, lacrimation, pinna and pain reflex absent, red-stained nose, mouth and eyes, brown-stained urogenital or anal region, dyspnea, bradypnea and piloerection. Gross necropsy revealed yellow-red stained perineum, red discharge around eyes, red areas on the thymus, perinasal discharge, stomach enlarged with gas, red mucosa, firm tan areas on the lungs and stomach and red kidney medulla. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801770 |
| Origin |
NTIS |
| Type |
CAT |
