| Main Title |
14-day Dermal Toxicity Range-finding Study of Oleylamine in Rats (Final Report) with Cover Letter Dated 04/11/1985. |
| CORP Author |
Intox Labs., Inc., Redfield, AR.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
40-8584196 |
| Stock Number |
OTS0525400 |
| Additional Subjects |
Toxicology ;
Health effects ;
Oleylamine ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 112-90-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525400 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
62p |
| Abstract |
Oleylamine was evaluated for subchronic toxicity in Sprague-Dawley rats (4/sex/dose group) receiving dermal applications of 0, 0.3, 1.5, or 3% oleylamine in mineral oil on the shaved back, 5 days/week for 2 weeks. These concentrations of oleylamine correspond to doses of 0, 12.5, 62.5 and 125 mg/kg bw/day, respectively. Oleylamine at a concentration of 0.3% induced mild to moderate skin irritation, whereas concentrations of 1.5% and higher produced moderate to severe irritation, occasionally progressing to hardening and sloughing of the skin. Rats in the 1.5% and 3% groups were sensitive to touch. Body weight of males was significantly reduced in the 1.5% (p < 0.02) and 3% (p < 0.04) groups. Food consumption, expressed on a per-weight basis, was not significantly affected by treatment with oleylamine. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802600 |
| Origin |
NTIS |
| Type |
CAT |
