Main Title |
1,3-dichloro-2-propanol: 13-week Gavage Toxicity Study in Sprague-dawley Rats (Final Report) with Cover Letter. |
CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1989 |
Report Number |
40-8915319 |
Stock Number |
OTS0526377 |
Additional Subjects |
Toxicology ;
Health effects ;
1 ;
3-dichloro-2-propanol ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 96-23-1
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0526377 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
79p |
Abstract |
1,3-Dichloro-2-propanol (DCP) was evaluated for subchronic toxicity in Sprague-Dawley rats (10/sex/dose group) administered dose levels of 0, 0.1, 1, 10, or 100 mg DCP/kg bw/day by gavage in distilled water 5 days/week for 13 weeks. No adverse clinical signs were observed during the study in any dose group. Final body weight gain was 8% lower in high-dose males than in control rats. Sporadic decreases in food consumption were observed in high-dose males and females. Exposure to 100 mg/kg DCP induced a statistically significant decrease in hemoglobin and hematocrit in both sexes. High-dose females showed a significant increasein urinary proteins, but this effect was not observed in males. Numerous clinical chemistry effects detected were a reflection of liver damage in high-dose males and females and of kidney damage in high-dose females. Absolute and relative liver and kidney weights were significantly increased in high-dose groups. Gross pathology effects attributed to DCP-treatment were limited to gastric irritation in the 10 and 100 mg/kg groups. Histopathological alterations due to treatment with DCP were confined to the stomach, liver, and kidney of rats given 10 and 100 mg/kg, and to the nasal tissues of rats in the high-dose groups. The 1 mg/kg dose was the no-adverse-effect level. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
1989 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A06/MF A06 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028802700 |
Origin |
NTIS |
Type |
CAT |