| Main Title |
Two-week Repeated Dose Inhalation Toxicity Study of Hexamethyldisiloxane in Albino Rats with Cover Letter dated 04/20/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
8EHQ-86940001809 |
| Stock Number |
OTS0572321 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexamethyldisiloxane ;
Toxicity ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
CAS No 107-46-0 ;
Toxic substances ;
Laboratory animals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572321 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
41p |
| Abstract |
A study was conducted to evaluate the potential toxicity of hexamethyldisiloxane following inhalation exposure. Three groups of 5 male and 5 female Sprague-Dawley rats were exposed via inhalation to concentrations of 0, 499 ppm, or 1004 ppm hexamethyldisiloxane, for 6 hours per day, 5 days per week, for 2 weeks. The animals were observed daily for mortality or treatment-related toxicity, including respiratory, dermal, behavioral, nasal, and ocular effects and/or body weight changes. Following the final exposure, animals were sacrificed and gross pathological exams, including weighing of organs, as well as histopathological exams were conducted. All animals survived to terminal sacrifice. There were no significant differences in mean body weight in treated animals compared to controls. In the males only, there was a dose-related trend toward increased mean kidney weight. When expressed as kidney to body weight and kidney to brain weight ratio statistically significant increases were observed in the 1000 ppm males. These organ weight changes appeared to correspond with an increased severity of hyaline droplets in the proximal convoluted tubule, ie. hydrocarbon nephropathy, of the treated male rats. Hydrocarbon nephropathy is unique to male rats and is not observed in humans. No other significant toxicological effects were observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804070 |
| Origin |
NTIS |
| Type |
CAT |
