| Main Title |
Transmittal Letter from Informatics General Corp to Us Epa Regarding Submission of Health & Safety Studies and Lists of Studies with Attachments. |
| CORP Author |
Informatics General Corp., Rockville, MD.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1983 |
| Report Number |
40-8362017 |
| Stock Number |
OTS0527960 |
| Additional Subjects |
Toxicology ;
Health effects ;
4-(1 ;
1 ;
3 ;
3-tetramethylbutyl)phenol ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Rabbits ;
Dermal ;
Primary Eye Irritation ;
Inhalation ;
Primary Dermal Irritation ;
Toxic substances ;
Laboratory animals ;
CAS No 140-66-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0527960 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
38p |
| Abstract |
Octylphenol was tested for acute toxicity to laboratory animals. Summary reports indicate oral administration of single doses of 5.0 g/kg as a 25% suspension in corn oil to 6 adult albino rats led to total mortality within 2 days post-treatment. Diarrhea, lethargy, and gastro-intestinal inflammation were observed. Single application of 2.0 g/kg undiluted test material under occlusion to clipped abraded or unabraded rabbit skin did not yield evidence of systemic toxicity; severe erythema and moderate edema were observed at treatment sites. Single instillation of 0.1 ml octylphenol into the right eyes of 6 albino rabbits led to severe corneal, iridial and conjunctival effects that persisted for 7 days post-treatment. Individual animal data are provided. Acute inhalation exposure (1 hour duration)of adult albino rats to a 45% (w/v) solution of octylphenol (116 mg/L concentation) in isopropyl myristate led to total mortality within 24 hours, respiratory distress and pulmonary hemorrhage. Exposure of 6 New Zealand albino rabbits to 0.5 g of test material introduced under occluded patch to closely clipped skin on the back and sides of the body for 4 hours led to slight erythema in 4 animals (mean primary irritation score of 0.2); all signs of irritation disappeared by 24 hours post-exposure, indicating octylphenol was not corrosive under the conditions of this test. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Rohm and Haas Co., Philadelphia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1983 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803000 |
| Origin |
NTIS |
| Type |
CAT |
