| Main Title |
Toxicological Investigationof Maleic Anhydride, Lot No. QB1151 with Cover Letter. |
| CORP Author |
Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
878214766 |
| Stock Number |
OTS-0206655 |
| Additional Subjects |
Health effects ;
Toxicity ;
Laboratory animals ;
Acute ;
Lethal doses ;
Signs and symptoms ;
Dose levels ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Maleic anhydride ;
CAS No 108-31-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206655 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1288p |
| Abstract |
In an acute toxicity study, male and female Sprague-Dawley rats (2 males and 3 females/group, except highest-dose level group which had 4 males and 1 female) were given single gavage exposures to maleic anhydride (as a 10% solution/suspension in corn oil). Dose levels of 316, 398, 501, and 631 mg/kg resulted in the deaths of 0, 1, 3, and 4 animals, respectively (duration of observation period was not reported although the survival time was reported to be one to four days). The LD50 is 495 (410 to 580) mg/kg. Toxic symptoms observed included loss of appetite, diarrhea, and increasing weakness. Gross pathology observed at autopsy included renal and liver congestion, and inflammation of the gastric mucosa. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
5 Nov 1984 |
| Category Codes |
57Y |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019001840 |
| Origin |
NTIS |
| Type |
CAT |
