| Main Title |
Toxicity Study of Dow Corning 200 Fluid (10 CST) by Dermal Administration to Rabbits for 28 Days with Cover Letter dated 07/06/1999. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Huntingdon Life Sciences, Ltd., Princeton, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1999 |
| Stock Number |
OTS0573891 |
| Additional Subjects |
Toxicology ;
Health effects ;
Dimethyl silicones and siloxanes ;
Subchronic toxicity ;
Mammals ;
Rabbits ;
Dermal ;
CAS No 63148-62-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573891 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
190p |
| Abstract |
The objective of this study was to aid the assessment of the systemic toxic potential of Dow Corning 200 Fluid, 10 cSt in a 28 day dermal study in the rabbit. The study was performed in general compliance with the United States Environmental Protection Agency Guideline 798.2250 (Toxic Substances Control Act, September 1985; revised through 1 July 1991; amended 19 June 1995), 'Dermal Toxicity Study for 90 days'. Some aspects of this guideline were modified to be appropriate for a 28 day dermal toxicity study in the Rabbit. Dow Corning 200 Fluid, 10 cSt was administered by dermal application to three groups of 10 male and 10 female New Zealand White rabbits for four weeks at dosages of 100, 300 or 1000 mg/kg/day. The test substance was removed after six hours of exposure on each day of treatment. A similarly constituted fourth group, serving as Controls (Sham Controls), were subjected to the same procedures as the treated animals, but no test substance was applied. Throughout the study the animals were observed daily for signs associated with treatment. Before each administration the dermal test site was examined for signs of irritation. Bodyweights were determined twice each week and food consumption once each week. Blood samples were taken for haematology and blood chemistry investigations on Day 30 for males and Day 31 for females. After a minimum of 29 days of treatment the animals were sacrificed and subjected to a full macroscopic examination. Selected organs were weighed and tissues were processed and examined microscopically. There were no deaths and no adverse signs considered to be related to treatment. Ungroomed coat for animals receiving 300 or 1000 mg/kg/day and males receiving 100 mg/kg/day was considered to be a result of the accumulation of test substance around the application site. Bodyweight, bodyweight change and food consumption were not considered to be affected by treatment. There were no ophthalmoscopic findings attributable to treatment and haematological and blood chemistry investigations did not reveal any findings oftoxicological significance. Organ weights were considered to be unaffected by treatment. There were no treatment-related macroscopic findings at necropsy and there were no histopathology findings that were considered to be related to treatment. Dermal application of Dow Corning 200 Fluid, 10 cSt to rabbits at dosages of 100, 300 or 1000 mg/kg/day for at least 29 days did not reveal any local or systemic reactions to treatment, therefore the No-Observed-Effect-Level (NOEL) for this study was 1000 mg/kg/day. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
12 Jul 1999 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A10/MF A10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028701930 |
| Origin |
NTIS |
| Type |
CAT |
