| Main Title |
Toxicity Studies on Oil Additives: One Generation Reproduction Study in Male Rabbits Repeatedly Treated Dermally with Sap 011 for 10 Weeks Cover Letter 05/04/1984. |
| CORP Author |
Shell Oil Co., Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
40-8471080 |
| Stock Number |
OTS0507494 |
| Additional Subjects |
Toxicology ;
Health effects ;
Naphthenate Calcium ;
Subchronic Toxicity ;
Mammals ;
Rabbits ;
Dermal ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 1338-24-5 ;
CAS No 61789-36-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0507494 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
69p |
| Abstract |
SAP 011 (containing calcium naphthenate, purity not reported) was evaluated for reproductive toxicity in 12 male rabbits receiving once daily occluded applications of 2 ml undiluted SAP oil, 6 hours/day, 5 days/week for 10 weeks followed by mating. Control animals received identical applications of the 'carrier oil' component present in SAP 011. No systemic toxicity, application site toxicity, or statistically significant changes in body weights were observed in male animals during the 10 week exposure or 12 week post mating periods. Additionally, no significant differences in testes weights were observed in male animals sacrificed after either period. The treatment did not affect the number of males achieving one viable litter, two viable litters, or two pregnancies. The number of implantations, pre- and post- implantation losses, and viable fetuses were not significantly different in females mated with exposed males, compared to those mated with unexposed males. The investigators reported that there were no macroscopic or microscopic pathological findings in the male reproductive tract that could be related to SAP 011 exposure. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1984 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801230 |
| Origin |
NTIS |
| Type |
CAT |
