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RECORD NUMBER: 1908 OF 2096| Main Title | Teratology Study in the Rabbit Using Thiram with Cover Letter Dated 04/05/1988. | |||||||||||
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| CORP Author | Life Science Research; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | 86-880000181 | |||||||||||
| Stock Number | OTS0514070 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Thiram (137-26-8) ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 137-26-8 | |||||||||||
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| Collation | 82p | |||||||||||
| Abstract | Repro- ductive toxicity of thiram was evaluated in artificially inseminated New Zealand white rabbits dosed (number in dose group) 0 (18), 1 (15), 2.5 (18), 5 (20), and 0 (14) mg/kg/day by gavage gestation days (GD) 6-19. Maternal mortalities for the doses listed above were 1/18, 1/15, 2/18, 4/20, and NR/14, respectively. Necropsies indicated deaths were not compound-related, but due to respiratory or gastro-intestinal tract disorder, or tracheal intubation. Maternal weight gain for low and mid dose groups was similar to the second and superior to the first control group (which was considered to perform poorly relative to historical controls), while that for the high dose group was similar to the first control and inferior to the second (p<0.05 GD 6-10, 12, 16, and 18; p<0.01 GD 6-14). Abortions (and total litter resorptions) for the dose groups above were 1 (0)/18, 0(0)/15, 0(1)/18, 1(1)/20, and 0 (0)/14. Thiram was not considered the source of loss due to absence of increased postimplantation losses. No significant differences were reported for corpora lutea count, total implantations, viable young, sex ratio, early or late resorptions, pre- or post-implantation losses, or fetal and placental weights. A slight reduction of incidence of fetuses with both incisors erupted in the high dose group was within range of historical controls. | |||||||||||
| Supplementary Notes | The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Availability Notes | Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. | |||||||||||
| PUB Date Free Form | 1988 | |||||||||||
| Category Codes | 57Y; 57U; 68G; 99; 44G | |||||||||||
| NTIS Prices | PC A06/MF A06 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 028801900 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |