| Main Title |
Teratology Study in Rats with Lx1106-01 (Final Report) with Attachments and Cover Letter Dated 04/24/1991 (Sanitized). |
| CORP Author |
Bio-Dynamics Research and Development Corp., Eugene, OR.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
86-910000809S |
| Stock Number |
OTS0529441 |
| Additional Subjects |
Toxicology ;
Health effects ;
Solvent Naphtha (petroleum) Light Aromatic (64742-95-6) ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 64742-95-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0529441 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
404p |
| Abstract |
Solvent Naphtha, light aromatic (C8-10) (CAS No. 64742-95-6) was evaluated for maternal and developmental toxicity. The test substance was administered by oral gavage to mice (24 mated females/group) on gestation days 6-15 at dose levels of 0, 125, 625, and 1,250 mg/kg/day. As compared to controls, animals treated with 125 mg/kg/day and above had a slightly increased incidence of excessive salivation. At 625 mg/kg/day and above, maternal weight gain and food consumption was significantly reduced, compared to controls. At 1,250 mg/kg/day, there was staining of the anogenital area, alopecia of the legs, reduced fetal weights, and increased incidence of skeletal malformations. No other embryotoxic or teratogenic effects were noted at any dose level. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1991 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A19/MF A19 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803100 |
| Origin |
NTIS |
| Type |
CAT |
